Principal Software Engineer,
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Requirements
• This role is ideal for an experienced engineer who enjoys hands-on development, mentoring others, and bringing modern capabilities—including AI-assisted and agentic workflows—into production-grade systems. • hands-on development • bringing modern capabilities—including AI-assisted and agentic workflows—into production-grade systems • Take the first step toward your dream career. Here is what we are looking for in this role. • Bachelor’s or Master’s degree in Computer Science or equivalent practical experience • 10+ years in software design and development using the Microsoft technology stack preferred • Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs) • C#, .NET, and ASP.NET (MVC/Web APIs) • Strong experience building full-stack web applications (Angular, TypeScript, HTML, CSS) • full-stack web applications • Solid understanding of software design principles, patterns, and best practices • software design principles, patterns, and best practices • Experience across the full Software Development Lifecycle (Agile preferred) • Software Development Lifecycle • Proven ability to work independently while collaborating effectively in a fast-paced environment • Excellent communication, documentation, and technical leadership skills • Hands-on experience integrating LLM-based services (e.g., OpenAI, Azure OpenAI, or similar) into applications • LLM-based services • Experience using Python and/or .NET alongside AI/LLM workflows • Python and/or .NET • Familiarity with agent-based or workflow-driven AI architectures is a strong plus • agent-based or workflow-driven AI architectures • Understanding of secure and responsible AI usage in enterprise systems • Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning • Experience with microservices, distributed systems, and cloud platforms (AWS preferred) • microservices, distributed systems, and cloud platforms (AWS preferred) • Secure development experience, including awareness of common vulnerabilities and mitigations • Experience with clinical trial data, life sciences, or regulated SaaS environments • Experience building data visualizations or analytics-driven user experiences • data visualizations • Accelerate your skills and career within a fast-growing company while impacting the future of healthcare. We have shared our story, now we look forward to learning yours! • eClinical is a winner of the 2025 Top Workplaces USA Award for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards celebrating our exceptional company vision, values, and work-life balance. See all the details here: https://topworkplaces.com/company/eclinical-solutions/ • eClinical Solutions is a people first organization. Our inclusive culture values the contribution that diversity brings to our business. We celebrate individual experiences that connect us and that inspire innovation in our community. Our team seeks out opportunities to learn, grow and continuously improve. Bring your authentic self, you are welcome here!
Responsibilities
• As a Principal Full Stack Software Engineer, you will be a technical leader within the elluminate Product Development team. You’ll help design and build the core services and user experiences of a next-generation clinical data and analytics platform—while influencing architecture, engineering standards, and technical direction. • Principal Full Stack Software Engineer • technical leader • Design, develop, test, and deploy scalable, secure, and highly interactive web applications • scalable, secure, and highly interactive web applications • Own and evolve core platform modules, from concept through release and support • core platform modules • Influence application and system architecture with a focus on performance, reliability, security, and maintainability • performance, reliability, security, and maintainability • Lead by example through clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions • clean, well-tested code • Collaborate closely with Product Management, QA, and other engineers throughout the SDLC • Provide technical mentorship and guidance to other engineers on the team • Diagnoses and resolves complex production issues across distributed systems • Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations • eClinical Solutions quality standards • Contribute to technical documentation including design specs, acceptance criteria, and release notes • AI & Modern Engineering Focus • We’re actively incorporating AI-powered capabilities into our platform, and you’ll help shape how this is done responsibly and effectively in an enterprise environment. This includes: • AI-powered capabilities • Integrating LLMs and AI services into .NET- and Python-based systems • LLMs and AI services • Designing and implementing AI-assisted workflows, copilots, or intelligent automation features • AI-assisted workflows • Working with agentic AI patterns (e.g., task orchestration, tool-using agents, workflow automation) • agentic AI patterns • Collaborating with data and platform teams to operationalize AI—not just prototype it • Deep ML expertise is not required—we’re looking for strong engineers who understand how to apply AI capabilities in real products.
Benefits
• $152,000 - $190,000 USD • Create a Job Alert • Interested in building your career at eClinical Solutions? Get future opportunities sent straight to your email.