Isomorphic Labs - Research Lead / Senior Scientist (DMPK), London

• Essential: • Essential: • PhD in either Pharmaceutical Science, Pharmacy, Chemistry, or another relevant subject. • 8+ years’ professional experience as a DMPK Lead, solving DMPK-related problems in drug discovery with a track record of working collaboratively to deliver high quality candidates. • Experience in supporting DMPK across multiple modalities. • Comprehensive understanding of drug metabolism, pharmacokinetics, PKPD principles, and translational research. • Practical experience developing DMPK and quantitative pharmacology packages to support early clinical development, including authoring and reviewing regulatory documents, ideally in oncology or immunology. • Experience of partnering closely with Preclinical and Clinical teams. • Demonstrated cross-functional leadership and exceptional interpersonal, communication, and collaborative problem-solving capabilities. • In depth knowledge of biotransformation. • Experience of utilising and applying NAMs to further project understanding • Strategic thinker with strong communication skills, capable of working across multiple disciplines • Advanced knowledge of PKPD modelling. • Good understanding of machine learning techniques. • Familiarity with R, Python and KNIME. • Culture and values • Culture and values • We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it. • ThoughtfulThoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. • Thoughtful • BraveBrave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. • Brave • DeterminedDetermined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we. • Determined • TogetherTogether at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere. • Together • Creating an extraordinary company • We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact. • We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know. • Hybrid working • Hybrid working • It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call. • would require you to be able to come into the office 3 days a week • Please note that when you submit an application, your data will be processed in line with our privacy policy. • >> Click to view other open roles at Isomorphic Labs