Natera - Lead Product Manager, Clinical Genomics
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Requirements
• Bachelor’s degree in life sciences, engineering, computer science, statistics, or equivalent experience • 7+ years of experience in software product management, including ownership of complex, multi-team or platform-level initiatives • 5+ years experience working on production software in healthcare, clinical genomics, or other regulated lifesciences domains, with demonstrated impact on validation, compliance, and system scalability • Demonstrated experience influencing engineering architecture and long-term technical investment decisions • Proven ability to drive alignment across highly matrixed organizations without direct authorityTrack record of independently operating in ambiguous environments and establishing product direction • Preferred • Preferred • Experience with clinical genomics and variant processing and interpretation workflows • Experience owning user-facing applications, tools, or operational software • Familiarity working with backend services, APIs, or data-driven systems • Ability to operate effectively at both tactical and strategic levels, connecting detailed execution to broader platform vision. • Strong analytical skills with attention to quality, reliability, and user outcomes • Leads technical design discussions and critically evaluates architectural tradeoffs to ensure scalability, reliability, and regulatory integrity • Proven ability to influence without authority and drive alignment across teams • Clear, concise written and verbal communication skills across technical and non-technical audiences • Ability to manage multiple initiatives in a fast-paced, regulated environment • Familiarity with Next Generation Sequencing concepts is beneficial • The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations. • $143,200 - $179,000 USD • OUR OPPORTUNITY • OUR OPPORTUNITY • Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. • The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.
Responsibilities
• Define and drive multi-year product strategy and roadmap across one or more RIR components, ensuring alignment to clinical quality, regulatory requirements, and commercial scale objectives • Influence platform-level technical direction in partnership with engineering leadership • Partner closely with software engineering, bioinformatics, clinical domain experts, quality, regulatory, and other product teams • Translate business, clinical, and operational needs into clear, actionable product requirements • Define and evolve end-to-end user workflows, including UI/UX requirements and supporting backend functionality • Drive cross-team alignment on shared data contracts and workflow standards • Mentor and raise the bar for product management within the RIR organization • Own measurable improvements in clinical workflow efficiency, reliability, and operational scalability • Establish prioritization frameworks that balance regulatory risk, clinical impact, technical scalability, and business outcomes across RIR investments. • Develop and track quantitative metrics related to usability, performance, reliability, and adoption • Lead delivery teams with clear strategic direction, ensuring requirements reflect long-term platform goals, validation readiness, and system interoperability. • Proactively identify systemic risks, architectural constraints, and workflow inefficiencies that may limit scale or regulatory robustness, and lead cross-functional initiatives to resolve them • Partner with Quality and Regulatory leadership to shape validation strategy, risk classification, traceability, and audit readiness for RIR software systems. • Create clear, data-driven written proposals and presentations to support stakeholder alignment and decision-making • Act as a subject matter expert for owned components, supporting design, testing, validation, rollout, and ongoing use
Benefits
• Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program! • For more information, visit www.natera.com.
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