kariusdx - Senior Clinical Data Scientist

Redwood City, CA (Hybrid) or Remote (USA) - Hybrid1mo ago

In Office Senior NA Genomics Clinical Research Data Scientist Senior Data Scientist SQL Reporting ACCA Documentation Data Quality Data Visualization Data Governance

Requirements

• Why Should You Join Us?Karius aims to conquer infectious diseases through innovations around genomic sequencing and machine learning. The company’s platform is already delivering unprecedented insights into the microbial landscape, providing clinicians with a comprehensive test capable of identifying more than a thousand pathogens directly from blood, and helping industry accelerate the development of therapeutic solutions. The products Karius offers today are some of the most advanced solutions available to physicians who aim to deliver better care to many otherwise ineffectively treated patients. Our tests are the result of some incredible work done by our scientists, statisticians, engineers, and physicians, all driven by the same mission. You, as part of the Karius team, will be able to see how directly your work has a life-changing impact on people, and at scale. • Reports to: Director, Clinical Statistics and Data Management • Location: Redwood City, CA or Remote • Strong technical aptitude, including the ability to write and interpret complex SQL queries. • Ability to translate technical clinical data requirements into clear, practical guidance for non-technical stakeholders. • Strong attention to detail and comfort working with complex data sharing specifications. • Intellectual curiosity and sound judgment when evaluating clinical data, workflows, and downstream implications. • Ability to move fluidly between hands-on technical work and stakeholder-facing communication. • Collaborative communication style, with the ability to partner effectively with site coordinators, clinical teams, and cross-functional stakeholders.

Responsibilities

• Own EHR data extraction specifications for the AXIS registry, including data element definitions, data dictionaries, field mappings, and site-specific translation logic across heterogeneous EHR environments. • Serve as the primary technical liaison to site informatics and IT teams, translating clinical research data requirements into executable data queries and extraction protocols; primary experience with Epic Clarity and/or Caboodle required. • Design and validate data extraction pipelines that ingest structured EHR data (diagnoses, medications, labs, procedures, utilization) from multiple health systems into a harmonized, analysis-ready format. • Perform data quality assessment, anomaly detection, and cross-site consistency validation; implement processes to identify and resolve data integrity issues with sites. • Partner closely with the biostatistics team to deliver clean, structured, well-documented datasets; support data preparation, variable derivation, and dataset specifications for statistical analysis plans. • Collaborate with clinical operations on site onboarding for clinical site data integration, including support for data governance agreements, BAAs, and technical feasibility assessments. • Build and maintain the registry data model, data lineage documentation, and codebook to ensure reproducibility and audit-readiness. • Support seamless integration between EHR data, the registry EDC, and Karius' standardized internal clinical database. • Support broader clinical research data analytics across programs, including integrating datasets from multiple sources, building analysis-ready analytic files, and data visualization to support clinical development and biostatistics teams • Contribute to the design of data collection strategies for future real-world evidence studies and registry expansions. • What’s Fun About the Job?Karius is operating at the edge of what is now known to be possible in diagnostics. With that, comes a wave of new and incredible challenges and opportunities. To deliver on that value, you will be tapping into some of the most advanced technologies, architecting and innovating where the current solutions simply don't suffice. You will get to see how much your work really matters. • Travel: Up to 20%. • Physical RequirementsSubject to extended periods of sitting and/or standing, vision to monitor and moderate noise levels. Work is generally performed in an office, lab or clinical environment. • Travel: Up to 20%.