relationrx - Associate Director/Director Medicinal Chemistry
Requirements
• Working with modalities such as peptides, ADCs, oligonucleotides or targeted delivery approaches • PERSONALLY, YOU • Are comfortable working in a matrixed environment, balancing multiple stakeholders and contributing effectively across teams. • Take ownership of your work, proactively seek opportunities to contribute, and enable others to do their best work. • Communicate openly and directly, give and receive feedback constructively, and handle challenging conversations with respect. • Actively seek out diverse perspectives, build strong working relationships, and contribute to shared goals across teams. • Embrace challenges with openness and resilience, set high standards for yourself, and strive to deliver meaningful outcomes. • WORKING STYLE & CULTURE AT RELATION • At Relation, we operate in a matrixed, interdisciplinary environment, where impact is driven through collaboration across scientific, technical, and operational domains. We collaborate, and you will partner with colleagues across multiple teams and projects, contributing your expertise while aligning to shared company priorities. We work together and win together! The patient is waiting! • RECRUITMENT AGENCIES • Please note that Relation does not accept unsolicited resumes from agencies. Resumes should not be forwarded to our job aliases or employees. Relation will not be liable for any fees associated with unsolicited CVs. • Relation is a committed equal opportunities employer.
Responsibilities
• Lead medicinal chemistry strategy across discovery programmes, applying deep expertise in small molecule drug discovery to drive scientific and portfolio impact • Lead medicinal chemistry activities from hit identification through to development candidate selection, using modern discovery approaches, synthetic organic chemistry and data-driven decision making to achieve key milestones and value inflection points • Design and optimise novel chemical matter using structure-based design and multiparameter optimisation to deliver high-quality molecules with balanced potency, selectivity and developability • Partner closely with cross-functional colleagues across biology, machine learning, translational sciences, toxicology, DMPK and related disciplines to solve complex scientific challenges and accelerate programme delivery • Lead and manage external collaborations and CRO partnerships, ensuring effective execution, clear prioritisation and delivery against timelines, budgets and project goals • Represent medicinal chemistry in project teams, governance forums and portfolio reviews, communicating scientific strategy, progress, opportunities and risks clearly to senior stakeholders • Contribute to the growth and evolution of Relation’s discovery capabilities by introducing new scientific approaches, maintaining awareness of advances in medicinal chemistry and drug discovery and driving continuous improvement • Champion Relation’s collaborative, ambitious and science-driven culture, mentoring colleagues and helping to build an exceptional drug discovery organisation • A PhD in medicinal chemistry, synthetic organic chemistry, or a related scientific discipline or equivalent experience in industrial drug discovery • Significant experience leading medicinal chemistry programmes within biotech, pharmaceutical or CRO environments • Demonstrated success progressing drug discovery programmes through lead optimisation to development candidate selection, with clear impact on project strategy and delivery • Deep expertise in modern medicinal chemistry approaches, including structure-based drug design, multiparameter optimisation, and the application of computational and data-driven methods to molecule design • Experience building and managing productive collaborations with CROs and external partners to deliver high-quality scientific outcomes • Strong record of scientific achievement and innovation, evidenced through publications, patents, presentations and progression of molecules into development • Passion for small molecule drug discovery, with curiosity for emerging technologies and enthusiasm for integrating computational approaches with experimental science • Excellent communication, influencing and interpersonal skills, with the ability to thrive in a collaborative, cross-functional, matrixed environment • Highly motivated, scientifically rigorous, and comfortable operating in a fast-paced, evolving biotech setting
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