Flagship Pioneering, Inc. - Associate Scientist, in vitro Pharmacology and Assay Development
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Requirements
• Proven experience advancing protein therapeutics through drug discovery phases to development. • Expertise in structure-based protein engineering and design of antibodies including (multispecifics, Fc engineering, fusion proteins etc) • Skilled in antibody engineering, including use of in silico, structure-based, and AI/ML approaches to sequence/CDR design, use of display technologies, humanization techniques, sequence liability remediation, analytics, and developability (biophysical) assessment and improvement • Project leadership experience in pharmaceutical industry R&D environment across multiple therapeutic areas, with a deep understanding of lead identification and optimization through preclinical development of antibody therapeutics • Track record of advocating for acquisition or creation of new technologies for accelerated antibody design, expression, and characterization • Experience in early-stage or start-up biotech environments • Experience working with genetic and genomics platform-driven drug target discovery • Broader understanding of protein sciences (expression, developability, and analytical purification and analysis) • Experience managing the design and validation of cellular assays for the functional characterization of engineered biologics • Values and Behaviors: • Encourage respectful disagreement and cultivate open-minded, ego-free interactions to continuously push each other towards excellence • Seek out diverse perspectives; practice active listening and genuine curiosity to ensure all contributions are valued, regardless of source • Recognize the impact of your behavior, language and attitudes, and strive for balanced, meaningful exchanges that enhance mutual growth and understanding in all interactions • Use a company-first mindset to guide decision-making; prioritize team over individual success • Take calculated risks and challenge convention in the quest for exceptional outcomes • Quotient Therapeutics is a privately-held, early stage company developing breakthrough medicines informed by natural somatic genetic diversity present in patients. Through our work in somatic genomics, we are forging a new status quo for biopharma research and development across a broad pipeline of internal and partnered programs. • The company was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS). • Quotient Therapeutics and Flagship Pioneering are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. • Recruitment & Staffing Agencies: • Quotient Therapeutics (“Quotient”) and Flagship Pioneering (“FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Quotient, FSP or their employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
Responsibilities
• AI Strategy, Governance & Use Case Portfolio Management • Translate Flagship's enterprise AI strategy into function-level execution by partnering with leaders across the firm on AI roadmap creation and delivery. • Run a regular cadence of engagement with each business and scientific function to surface, intake, and prioritize use cases. • Partner with the AI engineering team to shape use cases, supporting use case owners in identifying the right data, technology, and stakeholders for efficient and effective design. • Track use case value/ROI throughout the life cycle and for the AI program overall. • Drive solution reuse across functions by maintaining visibility into what has been built, by whom, and what is reusable. • Operate the AI Operational Governance Forum by surfacing relevant AI product, feature, and use case developments and supporting decision-making and tracking around risk management. • Support the evolution of Flagship’s AI strategy, policies, and roadmap by staying up to date on relevant industry trends and internal needs. • AI Education & Capability Building • Design and execute AI learning programs across the company that drive adoption while shaping responsible, secure, and cost-effective use of AI. • Build and oversee operations for the AI change champion network to scale AI adoption. • Develop reusable AI enablement assets and partner with Communications and Learning & Development to amplify. • Provide hands-on coaching to teams adopting AI tools across the business. • AI Tool & Vendor Management • Provide support on AI tool evaluation, procurement, and lifecycle management across enterprise-wide and function-specific applications. • Support ownership, administration, and governance of core enterprise AI platforms, including settings configuration, feature rollout, internal communications, and ongoing user support. • Support vendor relationships and contracts in partnership with Procurement and Legal; track usage, license utilization, and consumption against contracted commitments. • Coordinate with InfoSec on AI-specific risk reviews, ZDR posture, agentic sandbox governance, and shadow AI monitoring. • Maintain the AI tool intake and approval process and the AI Product / Use Case records in Flagship's GRC system of record.
Benefits
• Opportunity to work at the forefront of LNP formulation innovation • Collaborative, science-driven culture with high impact research • Competitive compensation and benefits package • LOCATION: Cambridge, MA • Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. • Flagship has been recognized twice on FORTUNE Change the World list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company annual list of the World Most Innovative Companies. Learn more about Flagship https://url.us.m.mimecastprotect.com/s/xLXBCqxk3LTk9pwcZf3CEkjif?domain=flagshippioneering.com. • At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.
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