latchbio - Ai Biologist - Peptide Discovery

• PhD in peptide chemistry, biochemistry, biophysics, structural biology, medicinal chemistry, or a related field • Senior, hands-on peptide discovery experience: you have personally analyzed real program data, not just supervised it • Direct experience with at least one of: display selection (phage, mRNA, ribosome, RaPID, or DNA-encoded libraries), SPR/BLI or FP binding kinetics, binding-site mapping by structural MS or NMR, or peptide developability (PAMPA/Caco-2 permeability, proteolytic and serum stability) • Deep expertise in at least one area (display and selection, biophysics, structural mapping, or peptide medicinal chemistry) and working fluency across the others • Strong command of experimental design, quantitative data analysis in Python or R, and statistics • AI-ready from day one: daily use of Claude, Cursor, or similar agents, with the judgment to spot where model reasoning is technically correct but scientifically unsound • Confidence to overrule an AI agent when the evidence demands it, and the openness to update when shown wrong • Ability to calibrate confidence and communicate uncertainty rather than defaulting to binary calls • Bonus: peptide format and chemistry experience, such as macrocyclization, hydrocarbon stapling, N-methylation, D- and non-canonical residues, or HELM encoding • Bonus: target tractability or de novo design experience, such as PPI hotspot analysis, human-genetic evidence for therapeutic direction, or computational design with Rosetta or RFdiffusion • Culture. We practice radical transparency: you’ll know how the company is doing, what’s working, and what isn’t. It’ll always be us against the problem, never each other. We’re opinionated but respectful, and we bring solutions with our problems. You decide how you work; we judge the output. We use AI constantly, so what we reward is original expert judgment, not AI output passed off as your own. You’ll start on the bench that fits your expertise and can move across teams as you build a track record. People who do well here and bring leadership experience can move quickly into senior roles. Outside of work, we have company outings most months, team off-sites, a Latch run club, cycling, boxing, ice skating, and soccer. Feel free to add to the list.