Flagship Pioneering, Inc. - Principal Scientist, Machine Learning - Multimodal Biological Reasoning

• Industry-leading expertise in modern LLMs, multimodal modeling, representation learning, fine-tuning, post-training, benchmarking, and ML systems. • Deep experience in computational biology, AI-for-biology, AI-enabled drug discovery, translational data science, biological foundation models, or scientific discovery platforms. • Demonstrated ability to work with scientists or biotech teams to scope high-value use cases, identify data assets, define success criteria, and translate discovery needs into technical execution plans. • Working knowledge of biological data modalities such as genomics, transcriptomics, perturbation data, protein sequence, protein structure, pathways, imaging, pathology, or time-series biological data. • Strong judgment around mechanism-of-action reasoning, target discovery, perturbation biology, scientific credibility, model limitations, hallucination risk, interpretability, and validation. • Experience leading small, high-caliber technical teams through ambiguous scientific or product problems. • Ability to communicate clearly with ML researchers, data engineers, portfolio-company scientists, executives, and venture creation leaders. • Comfort operating in an entrepreneurial environment where the goal is not only to build a model, but to create a new capability that can reshape company creation and scientific discovery. • PhD, MS, or equivalent experience in computational biology, machine learning, bioengineering, computer science, systems biology, quantitative biology, translational science, or a related field. • Experience in biotech, pharma, AI-for-science, AI drug discovery, venture creation, or a platform organization serving multiple scientific programs. • Experience deploying AI/ML for biology systems into scientific workflows at enterprise scale. • Experience with LLMs, biological foundation models, protein language models, genomic foundation models, scientific agents, or AI discovery platforms. • Experience working across multiple internal and external customers, therapeutic programs, or discovery teams. • Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. • Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com. • At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.