sandboxaq - Senior Computational Chemist, Drug Discovery
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Requirements
• PhD in computational physics, computational chemistry, or a related discipline. • 3-5 years of relevant experience, including hands-on experience with computational chemistry applied to drug discovery in biotech, pharma, or related industries. • Excellent communication skills and record of fostering successful internal collaboration and effective external partnerships. • A deep commitment to critical thinking - comfortable questioning methodologies, challenging assumptions, and refining approaches to improve predictive accuracy. • A drive to cooperate with colleagues to identify problems and communicate technical solutions clearly and effectively. • A hands-on mentality & comfortable with getting deep into the technical weeds of highly complex problems. • Track record of driving projects to completion • Proficiency in structure-based drug design and familiarity with ligand-based drug design methods. • Experience with GPU-accelerated MD codes like OpenMM. • Experience in the Python data science stack (NumPy, Pandas, SciPy, etc.). • Familiarity with ligand-protein free energy of binding prediction methods such as Free Energy Perturbation (FEP) or similar. • Experience running computational chemistry/quantum simulations on high-performance computing (GPU) environments for corporate R&D, innovation labs, or academic research. • A passion for solving scientific problems in chemistry and biology through computational and data-driven methods, with a commitment to rigorous validation and scientific integrity. • Ability to leverage both experimental and computational data in forming strategic drug discovery approaches. • This is a remote role based in the United Kingdom. • Experience in quantum chemistry and/or protein folding.
Responsibilities
• Apply computational solutions to address unmet drug discovery challenges, questioning assumptions and rigorously validating results. • Work closely with the development team to enhance SandboxAQ’s unique technology and Large Quantitative Models (LQMs) for large-scale impact. • Apply SandboxAQ’s computational platform to provide high-value drug discovery solutions while critically evaluating its methodologies and results. • Translate insights from molecular dynamics, free energy perturbation, molecular docking, quantum, and ML methods into actionable, testable drug discovery hypotheses. • Collaborate closely with ML experts and cross-functional teams to prototype and scale innovative drug design solutions. • Develop and deploy computational methods and workflows to generate and evaluate hypotheses, guiding design decisions and influencing project direction. • Challenge conventional thinking by critically assessing and interpreting computational outputs, ensuring robust scientific conclusions. • Directly contribute to the discovery of innovative medicines by integrating computational chemistry techniques into multidisciplinary drug discovery teams. • Generate and evaluate hypotheses to assist design decisions and influence project direction by deploying and developing computational methods and workflows.
Benefits
• UK Tier 1£68,400 – £102,600 • UK Tier 2£58,140 – £87,210 • At SandboxAQ, we are committed to competitive, equitable, and transparent compensation; we continuously benchmark our salaries and total compensation to premium markets to ensure our competitiveness. Individual pay within the above range is determined by job-related skills, experience, education, and geographic location. • With a focus on pay equity and ensuring opportunity for future salary progression, our typical practice is to hire within the first half of the base salary range for a given role and level. This approach allows us to reward performance and increasing expertise consistently as your career develops with us. • We use geographic pay tiers to reflect the pay differences in local markets:For the US: • For the US: • Tier 1: Applies to candidates within 50 miles of New York, San Francisco, San Jose, Seattle, Wash D.C., Boston • Tier 1: • Tier 2: Applies to candidates Within 50 miles of Portland, Boulder, Austin, Denver, San Diego, Miami, Houston, Dallas, Philadelphia, LA • Tier 2: • Tier 3: Everywhere else in the US • Tier 3: • For the UK: • Tier 1: Applies to candidates within 50 miles of London, Cambridge, Oxford • Tier 1: • Tier 2: Everywhere Else in the UK • Tier 2: • For Canada: • Tier 1: Applies to candidates within 50 miles of Toronto & Vancouver • Tier 1: • Tier 2: Everywhere Else in Canada • Tier 2: • Upload your resume here to autofill key application fields. • Drop your resume here! • Parsing your resume. Autofilling key fields... • Please Note: To ensure that candidates select the most relevant jobs for their skills, we have set up limits to the number of times candidates can apply. The following limits apply to all roles at SandboxAQ: • Candidates may not apply more than 5 times in any 60 days for any job • Candidates may not re-apply to the same role within 30 days if not presented with an offer • or drag and drop here • We're genuinely interested in your personal take here. While we appreciate AI for its efficiency, your authentic voice matters most to us. Please share your thoughts in your own words—two to four sentences is perfect. Our team personally reads and thoughtfully considers every response. • Do you agree to allow SB Technology, Inc. to contact you about job opportunities for up to 3 years? • Recruiting Privacy Policy • SandboxAQ may use Artificial Intelligence with this application. Learn more.
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