Shasqi - Principal Scientist, Toxicology & Pharmacology
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Requirements
• PhD, DVM, or equivalent in Toxicology, Pharmacology, or related discipline. • 4+ years of industry experience in nonclinical safety and/or pharmacology. • Demonstrated experience leading IND-enabling toxicology programs. • Strong background in small molecules, biologics, or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics). • Experience designing and interpreting in vivo toxicology and pharmacology studies. • Familiarity with regulatory expectations (FDA/ICH) for nonclinical development. • Experience with pre-targeting strategies. • Familiarity with bioorthogonal click chemistry (e.g., tetrazine–TCO systems). • Background in oncology or other areas involving targeted therapies. • Experience evaluating on-target vs. off-target toxicities in complex systems. • Knowledge of safety considerations for reactive intermediates or payload-driven toxicity. • Experience integrating PK/PD and tox data for translational modeling. • Strong publication record and presentation skills. • How We Work: • How We Work: • We are a remote-first company, with occasional travel for in-person team meetings or scientific conference attendance. • Core collaboration window: 9:00am–3:00pm Pacific Time. You are expected to be available during this time for meetings and real-time collaboration. • Async + sync balance: Outside of core hours, we work asynchronously, but timely communication and follow-through are expected. • Meetings: You should be comfortable joining video calls, sharing availability on calendar and actively participating during core hours. • You should be comfortable working across common tools including Zoom, Google Workspace, Microsoft 365, Slack, and similar platforms.
Responsibilities
• Nonclinical Safety Strategy • Contribute to and execute toxicology strategy for pre-targeted therapeutics, including IND-enabling studies. • toxicology strategy • Design GLP and non-GLP toxicology studies. • Identify, characterize, and mitigate safety risks. • Establish safety margins and therapeutic index for candidate molecules. • Pharmacology & Translational Science • Contribute to pharmacology strategy to demonstrate proof of mechanism and proof of concept. • Design and interpret in vivo efficacy studies including model selection/characterization, study design, working with CROs to execute the study, and data analysis/presentation. • Define exposure-response relationships. • Collaborate on dose and schedule optimization. • Cross-Functional Integration • Partner with ADME/PK to integrate pharmacokinetics, biodistribution, and exposure-response modeling. • Work closely with chemistry and protein engineering teams to guide design toward safer and more effective molecules. • Collaborate with CMC and analytical teams to ensure appropriate characterization of each therapeutic component. • Support regulatory strategy, including authoring and reviewing IND sections (e.g., nonclinical overview, tox summaries). • Risk Assessment & Decision Making • Develop safety assessment frameworks tailored to our pre-targeting approach. • Drive candidate selection by balancing efficacy, exposure, and safety. • Present findings and recommendations to leadership, board members, and external partners.
Benefits
• Competitive base salary as part of a broader total rewards package. • Equity: Included as port of total compensations. • Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability. • Flexible PTO and a WFH stipend to support remote work. • Ongoing growth opportunities, professional development, and mentorship. • The anticipated base salary range for this role is $150K–$180K USD. • $150K–$180K USD. • Final compensation will depend on location, experience, skills, education, and internal equity. • Our ranges are intentionally broad to reflect market conditions and the specialized nature of our work. • Eligibility • Eligibility • U.S.-based employees only. • Must be authorized to work in the United States. • We are not currently sponsoring visas. • Shasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry. Backed by leading biotech investors, we are building a pipeline of first-in-class therapies that are designed to overcome the limitations of ADCs increasing efficacy and limiting toxicities. Our lead asset will be entering the clinic in early 2027. • You can learn more about our company at www.shasqi.com • Please Note: • Please Note: • At this time, Shasqi is not partnering with external recruiting agencies. We kindly ask that agencies refrain from contacting us regarding this role.
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