Flagship Pioneering, Inc. - Director, Portfolio Strategy - Global Initiatives
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Requirements
• You are a scientifically trained strategist who thrives at the boundary of deep science and structured problem‑solving. You are comfortable operating with senior leaders and equally comfortable doing the work yourself—from framing questions to building analyses and influencing decisions. • PhD or MD in Life Sciences or a related field • 5+ years of experience in management consulting (strategy and/or life sciences), biotech venture creation or investing, biopharma portfolio strategy, or related roles • Strong understanding of biopharma R&D, clinical development, and regulatory pathways • Experience working across multiple programs and stages of drug development • Demonstrated experience with portfolio construction, scenario planning, and risk‑adjusted decision‑making • Exceptional ability to synthesize complex data and communicate clearly with executives • Proven ability to influence senior scientific and business leaders without formal authority • Experience within the Flagship ecosystem is strongly valued
Responsibilities
• Shape portfolio strategy and investment decisions across the BioMedicines pipeline, from preclinical inception through development • Build and advance new R&D programs, defining development paths, milestones, resourcing plans, and decision points • Develop integrated investment cases that synthesize scientific rationale, development feasibility, execution risk, and value creation • Lead portfolio reviews, scenario planning, and trade‑off analyses (e.g., indication selection, timing, resourcing, probability‑adjusted value) • Evaluate internal and external opportunities, including scientific, technical, strategic, and operational diligence of prospective assets • Identify portfolio risks, gaps, and opportunities and recommend actions such as acceleration, de‑prioritization, partnering, or termination • Translate complex scientific, clinical, and financial information into concise, executive‑level insights and decision materials • Collaborate across R&D, Clinical Development, Regulatory, CMC, Finance, Commercial, Partnering, and internal venture teams • Work directly with senior scientific and executive leaders (e.g., CSOs, CMOs, CBOs) to create and execute new programs • Support governance and decision‑making forums that enable speed, clarity, and accountability • Contribute to special strategic initiatives with the Head of Global Initiatives and SVP, Global Initiatives
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