Altos Labs - Senior / Principal Scientist, Medicinal Chemistry
Requirements
• Education and Experience: You possess a Ph.D. in Organic Chemistry with 6+ years of post-Ph.D. experience, or equivalent and relevant experience in chemical research, preferably within a biotechnology or pharmaceutical setting. • Expertise in Synthetic/Medicinal Chemistry: You have proven expertise in modern synthetic organic chemistry, demonstrated by a strong track record of lead author publications and/or patents and an understanding of medicinal chemistry principles. • Drug Discovery Acumen: You have experience in the drug discovery process from hit identification, hit-to-lead, and lead optimization. • Structure-Based Drug Design: Experienced with structure-based drug design. • Strong Communicator: You convey strong verbal and written communication skills and a demonstrated ability to deliver effective presentations. • Problem-Solver: You exhibit contemporary expertise and understanding of all aspects of organic chemistry, including modern synthetic methodologies, multi-step synthetic route design, compound purification, and characterization. • Collaborative Team Player: You are highly collaborative, team-oriented, and considerate of the needs of the team. • Results-Oriented: You are fearless in your pursuit of groundbreaking innovations and passionate about creating revolutionary medicines to address unmet patient needs.
Responsibilities
• We are seeking a talented and passionate Medicinal Chemist to join our small-molecule drug discovery team. In this role, you will advance science and develop life-changing medicines. You will impact all stages of drug discovery, from hit identification to lead optimization, within a collaborative and fast-paced environment. • Drive Drug Discovery Programs: Contribute to the chemistry efforts for one or more drug discovery programs, focusing on designing drug-like molecules and optimizing compounds towards drug development candidate selection. • Collaborate Cross-Functionally: Work closely with a diverse range of functions, including Drug Metabolism and Pharmacokinetics, Structural Biology, Biochemical and Cellular Pharmacology, Machine Learning, Pharmaceutical Sciences, Safety, and disease area Biology. • Design and Synthesize Novel Compounds: Apply innovative structure-based, computational, and property-based design tools and methods, and/or synthesize analogs for molecular targets. This includes conducting multi-step syntheses, retrosynthetic analysis of complex molecules, and troubleshooting synthetic issues internally or with CRO partners. • Analyze and Interpret Data: Utilize strong analytical thinking skills to organize, analyze and communicate structure-activity relationship (SAR) data sets to drive design ideas and impact program direction. • Solve Complex Problems: Design compounds that effectively address challenges related to potency, physical properties, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity). • Support Chemistry Operations: Execute synthesis within internal laboratories, collaborate with Contract Research Organizations (CROs), and provide broad general chemistry support to all functions within Altos Labs. • Communicate and Present: Deliver effective presentations and articulate scientific findings clearly to both internal and external stakeholders. • Potential for Leadership: Demonstrate leadership potential towards leading chemistry programs, including managing external CRO chemistry FTEs.
Benefits
• Senior Scientist I, Medicinal Chemistry: $174,800 - $224,100 • Senior Scientist II, Medicinal Chemistry: $215,200 - $275,900 • Principal Scientist I, Medicinal Chemistry: $246,600 - $316,100 • Senior Scientist I, Medicinal Chemistry: $166,100 - $212,900 • Senior Scientist II, Medicinal Chemistry: $197,400 - $253,100 • Principal Scientist I, Medicinal Chemistry: $243,600 - $312,300 • Exact compensation may vary based on skills, experience, and location. • For UK applicants, before submitting your application: • Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice)- This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment. • Equal Opportunity Employment • We value collaboration and scientific excellence. • We believe that a culture of belonging are foundational to scientific innovation and inquiry. At Altos Labs, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining an inclusive environment.
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