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Jobs(27,529)/CRO Role(187)/Isomorphic Labs (9) - Research Leader (Toxicology), London
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Isomorphic Labs

Isomorphic Labs - Research Leader (Toxicology), London

London - Hybrid3d ago
In OfficeSeniorEMEAPharmaceuticalsBiotechnologyCROLab DirectorCRODocumentationClosehypothesisHarness

Requirements

• Essential: • Essential: • PhD in Toxicology, Pharmacology, Biology, or related technical field, or equivalent industrial experience. • 8+ years of professional experience working in a senior toxicology role within a biotech or pharma setting. • Proven track record of delivering successful non-clinical safety strategies as a project representative across different therapy areas. • Demonstrated experience designing, implementing and filing successful IND packages for both small molecules and biologics. • Deep understanding of Global Regulatory Guidelines regarding safety assessment. • Experience of partnering closely with Discovery and Clinical teams. • Excellent communication (written and verbal), interpersonal and influencing skills, with an ability to work effectively in a cross-functional, collaborative team environment. • Track record of creative problem solving with a strong growth mindset, adaptability, willingness to challenge conventional thinking and eagerness to learn new concepts. • Board certification • Experience with peptides and other new modalities. • Good understanding of the application of AI/ML techniques in drug discovery • Culture and values • Culture and values • We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it. • ThoughtfulThoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. • Thoughtful • BraveBrave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. • Brave • DeterminedDetermined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we. • Determined • TogetherTogether at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere. • Together • Creating an extraordinary company • We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact. • We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know. • Hybrid working • Hybrid working • It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call. • would require you to be able to come into the office 3 days a week • Please note that when you submit an application, your data will be processed in line with our privacy policy. • >> Click to view other open roles at Isomorphic Labs

Responsibilities

• Portfolio deliverables • As a core member of project teams, tailor and implement project-specific safety assessment strategies with an AI-first approach to support small molecules and biologics. • Design screening cascades and mechanistic experiments to elucidate and mitigate safety risks, supporting project progression in a data-driven manner. • Provide technical expertise to develop SAR understanding of toxicology liabilities to enable optimisation of chemical and biological matter. • Define regulatory safety assessment packages to support successful acceptance by regulatory agencies. • Communicate clear integrated risk assessments and recommendations to internal stakeholders • Author and defend toxicology sections of regulatory documents. • CRO interactions • CRO interactions • Since Isomorphic Labs outsource all wet-lab work to external vendors, you will maintain and develop close relationships with the CRO network to: • Ensure high quality and timely data generation to support our portfolio projects. • Leverage the scientific expertise of our external collaborators to enhance the team's impact. • Oversee the delivery of data generation campaigns purposefully designed to support the development of AI-based toxicology models. • People • People • Empower fellow team members by sharing your expertise in toxicology, fostering a culture of continuous learning and mutual support. • Embrace and champion a culture of inclusion and continuous professional development.

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