Spyre Therapeutics - Vice President, Clinical Development

• Clinical Leadership: • Provide strategic leadership and medical expertise for the clinical development of our cutting-edge antibody portfolio in IBD. • Develop and continuously refine integrated clinical development plans aligned with corporate objectives, competitive landscape, and evolving scientific insights. • Serve as a hands-on study lead for the current platform trial as well as contribute to planning pivotal studies. • Personally contribute to protocol development, medical review, safety assessment, data interpretation, and study-level decision making for ongoing and future IBD clinical trials. • Support the efforts of the medical monitoring team which ensures timely responses to investigative sites, provides medical safety oversight, and supports the collection of high-quality, clinically robust data. • Program Strategy & Trial Execution: • Provide medical and scientific leadership for the design, conduct, analysis, and interpretation of clinical studies across all phases of development. • Lead protocol development, study conduct, data review, and interpretation for ongoing clinical trials, partnering closely with clinical operations, regulatory, biometrics, etc., to ensure successful execution. • Drive key development decisions through analysis of emerging clinical, translational, safety, and competitive data. • Chair or contribute to governance committees and cross-functional program teams. • Cross-functional Collaboration: • Partner closely with Regulatory Affairs, Biostatistics, Clinical Operations, Translational Sciences, Medical Affairs, CMC, Commercial, and Corporate Development teams to ensure coordinated execution of development strategies. • Promote a culture of scientific excellence, accountability, and collaboration. • Regulatory Interface: • Lead clinical and medical strategy for regulatory interactions globally. • Serve as a primary medical representative for regulatory submissions, including INDs, CTAs, briefing packages, BLAs, NDAs, and related responses. • Ensure development programs are conducted in compliance with global regulatory requirements and industry best practices. • Safety Oversight: • Provide ongoing medical oversight of participant safety and benefit-risk assessments across assigned programs. • Review and interpret emerging safety data and contribute to safety governance activities, including Data Monitoring Committees and internal safety review forums. • Support signal detection, risk management planning, and clinical risk mitigation strategies. • Leadership & Mentorship: • Lead and mentor a high-performing clinical development team as the company grows. • Contribute broadly to corporate strategy, organizational planning, and leadership initiatives. • Other duties as assigned.