Isomorphic Labs - Senior Research Investigator / Research Leader (Translational Pharmacology), London

• Essential: • Essential: • PhD or equivalent industrial/research experience in Neuroscience, Translational Medicine, Pharmacology, Cellular/Molecular Biology, or a related discipline. • Deep mechanistic understanding of neurodegenerative disease biology, including cellular and molecular drivers of pathology in complex, high-unmet-need indications. • Expert practical knowledge of translational models (in vitro, ex vivo, and in vivo), patient-derived cellular systems, and the design of robust screening cascades from Target ID through Hit-to-Lead/Lead Optimisation. • Demonstrated success in advancing therapeutic hypotheses through target validation and profiling novel chemical matter to build decision-quality data packages. • Proven experience designing, contracting, and managing external research studies with CROs and academic collaborators. • Experience collaborating closely with bioinformatics, cheminformatics, or computational biology teams, utilising data-driven approaches for target discovery and compound progression. • Highly collaborative, agile, and driven to thrive in a high-velocity, interdisciplinary team environment. • Track record of driving strategic compound de-risking and SAR in close collaboration with medicinal chemistry and DMPK teams. • Working knowledge of biophysical, biochemical, and cellular screening techniques (e.g., SPR, TR-FRET, mass spectrometry, high-content imaging) and how machine learning models interact with these assay outputs. • Broad biological experience in diseases of aging or neuroinflammation outside classical neurodegeneration. • Prior experience in early clinical biomarker discovery or target engagement assay development. • Culture and values • Culture and values • We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it. • ThoughtfulThoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. • Thoughtful • BraveBrave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. • Brave • DeterminedDetermined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we. • Determined • TogetherTogether at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere. • Together • Creating an extraordinary company • We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact. • We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know. • Hybrid working • Hybrid working • It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call. • would require you to be able to come into the office 3 days a week • Please note that when you submit an application, your data will be processed in line with our privacy policy. • >> Click to view other open roles at Isomorphic Labs